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Bioavailability of Vitamin MK-7 Enhanced in Milk-Fat Food Matrix

Study showed a significant difference for an emulsified vitamin formula compared to a standard powder suspension.

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By: Sean Moloughney

Editor, Nutraceuticals World

A recent study published in Nutrafoods compared serum vitamin K levels in healthy subjects after a single oral administration (1 mg) of MK7 (vitaMK7 Gnosis by Lesaffre) diluted in 1%-fat milk either as a powder or as a pre-emulsified dispersion (oil-water emulsion). MK7 plasma levels were controlled at baseline, 2, 4 and 8 hours.
 
Even if both formulations increased serum MK7 levels in all subjects, the results highlighted that, there is a highly significant difference for the emulsified vitamin formula.
 
As matter of fact, AUC analysis showed a highly significant increase in the bioavailability of MK7 over the 8 hours of observation using the emulsified formula compared to a standard powder suspension.
 
MK7 a type of vitamin K that plays a key role in cardiovascular and bone health as a cofactor of gamma-glutamyl carboxylase enabling the activation of several vitamin K-dependent proteins, particularly at the extrahepatic level. MK7 is essential for calcium utilization, helping build strong bones and inhibit arterial calcification.
 
Fortified dairy products represent an optimum way to improve the nutritional status of the fat-soluble vitamins, such as vitamin K2 as MK7. Dairy products have a relevant lipid component that ranges from 1-2% of skimmed milk to 9% in some fat concentrated yogurt.
 
Fortified milk is widely used around the world to help people get nutrients that may otherwise be lacking in their diets. Examples are vitamin D, vitamin A, vitamin B9 (folate), minerals and micronutrients.
 
“The sector of fortified milk and dairy products is very promising for vitamin K2. Fortification of dairy products with MK7 completes the ‘perfect combo’ for bone health (Ca++, Vit D and Vit K2), in an easy-to-use and highly bioavailable manner,” said Lorena Carboni, product support specialist of Gnosis by Lesaffre commenting the study results.  

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